James Merson, Ph.D., is the Chief Virology Officer at a stealth oncology biotechnology company. He is a member of the R&D Leadership Team, leading the viral vector platform. As the former Global Therapeutic Head of Infectious Diseases at Janssen, James lead R&D that resulted in approval of Cabenuva, line extensions of Symtuza & Juluca, 5 Ph3, 10 Ph2, and 8 Ph1 studies, 9 NMEs, and in-licensing of JNJ-0953 (antiviral drug conjugate for influenza PrEP) and JNJ- 3989 (siRNA for HBV for combination with HBV a therapeutic vaccine and anti-PD1 mAb).
James held more than 30 years of R&D experience in antivirals, vaccines and immuno-oncology at Pfizer, becoming SVP and CSO of Vaccine Immunotherapeutics Research Unit. As a member of the Vaccines leadership, he contributed to the approval of Prevnar 13 & 20 and ABRYSVO, and oversaw 4 Ph1/2 studies with oncology vaccines or oncolytic viruses combined with tremelimumab and sasanlimab, 2 Ph1 studies for ant-IgE vaccine and anti-nicotine vaccine. James was responsible for starting Pfizer vaccines in 2005 with the acquisition of PowderMed and Coley Pharmaceuticals, that resulted in the acquisition of Wyeth Pharmaceuticals. James was also responsible for Pfizer’s first build-to-buy partnership with Ignite Pharmaceuticals that generated a novel armed oncolytic vaccinia virus and was evaluated in combination with sasanlimab in a Ph1 study. As Therapeutic Head, Antivirals at Pfizer, he oversaw approval of Selzentry, 4 Ph2 studies, Pfizer’s first gene therapy program for HIV with Immusol, and the in-licensing of dalbavancin and anidulafungin.
He holds a Ph.D. in Microbiology and Immunology, Baylor College of Medicine, Houston Texas and a B.A. in Biology from Bellarmine College, Louisville, KY. James has held multiple SAB and Advisor positions, consulted for several Venture Capital companies, holds 5 patents and has 48 publications.